Two of the 27 institutes that make up the National Institutes of Health (NIH), nation’s medical research agency, the National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI) joined forces to execute on a project known as The Cancer Genome Atlas (TCGA). The TCGA mission is to catalog the genetic mutations responsible for cancer using genome sequencing and bioinformatics. They collaborated with the International Cancer Genome Consortium (ICGC), a collaboration of the world’s leading cancer and genomic researchers, to making the genome data available to a larger research community. TCGA faced challenges with transforming the genome data to ICGC format because of its high volume and variability. So, they used Data Virtualization to enable the transformation of this data in an efficient, accurate and scalable manner.